Ph.D. Tezi Görüntüleme

Student:	Emel HACIİSLAMOĞLU
Supervisor:	Prof. Ahmet Hakan YILMAZ
Department:	Fizik
Institution:	Graduate School of Natural and Applied Sciences
University:	Karadeniz Technical University Turkey

Title of the Thesis:	Comparison of Dose distributions and Organs at Risk Doses in Whole Breast Irradiation with 3dcrt, for-ımrt, inv-ımrt, Volumetrıc Arc Therapy and Helical Tomotherapy
Level:	Ph.D.
Acceptance Date:	20/6/2013
Number of Pages:	105
Registration Number:	Di962

Summary:

Purpose: This study compared conventional technique (three-dimensional conformal radiotherapy; 3DCRT) with forward intensity-modulated radiotherapy (for-IMRT) and invers intensity-modulated radiotherapy (inv-IMRT, Helical Tomotherapy; HT and Volumetric Arc Therapy; VMAT) intensity-modulated radiotherapy techniques for breast cancer in order to determine whether the use of intensity-modulated radiotherapy techniques would lead to improved dosimetry for the whole breast irradiation.

Materials and methods: Twenty-five patients previously treated with breast cancer were selected. The clinical target volüme (CTV) included whole breast. To evaluate CTV doses, rCTV volume defined consisted of the CTV retracted 5 mm from the skin surface. The critical structures included heart, right and left lungs, LAD and contralateral breast. Conventional and a series of invers IMRT plans were generated for comparison each other. A fractionation schedule of 50 Gy in 2 Gy/fraction. All beam energies were 6 MV in order to provide a more direct comparison with the HT plan. Comparative endpoints were planning target volume (rCTV) dose homogeneity and doses to crictical structures.

Key Words: Breast cancer, Whole breast radiotherapy, IMRT, HT.